triheteromeric proteins: physiological role of GluN2B subunits
نویسندگان
چکیده
8 Andrew J. Delaney, Petra L. Sedlak, Elenora Autouri, John M. Power and 9 Pankaj Sah 10 11 Queensland Brain Institute, 12 The University of Queensland 13 Brisbane, QLD, 4072 Australia 14 15 16 17 Running Title: 18 GluN2B / NR2B subunits and LTP in the amygdala 19 20 21 Correspondence to: 22 Pankaj Sah 23 Queensland Brain Institute 24 The University of Queensland 25 Brisbane, QLD 4072 26 Phone: + 61 7 334 66376 27 Fax: + 61 7 3346 6301 28 e-mail: [email protected] 29 30 Current Address: 31 School of Biomedical Sciences 32 Charles Sturt University 33 Orange, NSW 2800. 34 Australia 35 36 School of Medical Sciences 37 The University of New South Wales 38 Sydney, NSW 2052 39 Australia 40 41 42 43 . 44 45 Articles in PresS. J Neurophysiol (December 5, 2012). doi:10.1152/jn.00176.2012
منابع مشابه
Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits.
N-methyl-(D)-aspartate (NMDA) receptors are heteromultimeric ion channels that contain an essential GluN1 subunit and two or more GluN2 (GluN2A-GluN2D) subunits. The biophysical properties and physiological roles of synaptic NMDA receptors are dependent on their subunit composition. In the basolateral amygdala (BLA), it has been suggested that the plasticity that underlies fear learning require...
متن کاملMg2+ block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
Native NMDA receptors (NMDARs) are tetrameric channels formed by two GluN1 and two GluN2 subunits. So far, seven NMDARs subunits have been identified and they can form diheteromeric or triheteromeric NMDARs (more than one type of GluN2 subunit). Extracellular Mg(2+) is an important regulator of NMDARs, and particularly the voltage dependence of Mg(2+) block is crucial to the roles of NMDARs in ...
متن کاملIdentifying the Role of GluN2A in Cerebral Ischemia
The activity of the NMDA receptor (NMDAR), which is a glutamate-gated ion channel, is a key factor influencing the neuronal damage following cerebral ischemia. NMDAR is composed of two essential GluN1 subunits and two regionally localized GluN2 or GluN3 subunits. GluN1, GluN2A, and GluN2B are the primary NMDAR subunits in the adult forebrain. Thus, the three major NMDAR subtypes in the adult fo...
متن کاملDistinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors
NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor-expressing cells, and the majority of native receptors are triheteromers containing two GluN1 and two different GluN2. In contrast to diheteromeric NMDA receptors, little is known about the function of triheteromers. We de...
متن کاملAn increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging.
The NMDA receptor is an important component of spatial working and reference memory. The receptor is a heterotetramer composed of a family of related subunits. The GluN2B subunit of the NMDA receptor appears to be essential for some forms of memory and is particularly vulnerable to change with age in both the hippocampus and cerebral cortex. GluN2B expression is particularly reduced in frontal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012